NAD+ Supplements Really Work? 5 Things to Know About It

NAD+ Supplements Really Work? 5 Things to Know About It

Nicotine adenine dinucleotide (NAD) is a naturally occurring molecule in the body, and its levels decrease with age. As such, there has been a continuous search for ways to continue feeling young. Fortunately, researchers are discovering anti-aging supplements like NAD+ that can slow the signs of aging.

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NAD boosters are attracting lots of discussion worldwide for their anti-aging benefits. In addition, NAD+ supplements may curb diseases and conditions associated with old age. Because of its potential benefits, you need to know some essential things.

Read on as we explore NAD+ supplements.

What is NAD+?

Nicotinamide adenine dinucleotide, or NAD, is a molecule (coenzyme) that occurs naturally in the human body. NAD exists in two forms, including NAD+ and NADH. In the realm of NAD, NAD+ stands out. The “+” refers to the oxidized form of NAD.

NAD coenzymes bind with enzymes to help initiate and accelerate the body’s healthy function. NAD is an essential component of bodily processes, such as;

  • Oxidation-reduction reaction assists in the body’s energy metabolism
  • Enzyme activities, including regulating metabolism and circadian rhythm
  • Cellular functions, including DNA repair, cellular senescence, and immune cell function


Our bodies produce less NAD as we age. NAD depletion appears to be connected to age-related problems like cancer, cognitive decline, and sarcopenia. But with the help of nmn supplements  we can boost healthy longevity and prevent or reverse age-related conditions. These products are created to help boost the amount of NAD+ circulating in the bloodstream.

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Ingredients Used in NAD+ Supplements

NAD supplements are currently available in the market. They are made with precursors to NAD. Precursors are substances the body can transform into another form during a metabolic reaction. Consuming foods with precursors helps in increasing NAD levels. Examples of precursors used in supplements include;

  • Niacin
  • Nicotinamide riboside (NR)
  • Nicotinamide mononucleotide (NMN)
  • Nicotinic Acid (NA)
  • Nicotinamide (NAM)
  • Tryptophan (TRP)

5 Things to Know about Using Nad+ Supplements

NAD supplements are reported to have numerous benefits. However, more research is required to truly comprehend the effects of taking NAD+ supplements. Without further ado, here are some of the potential benefits of taking these boosters;

1.    Improves Cognitive function

Low levels of NAD are linked to neurodegenerative disorders like Alzheimer’s disease, dementia, and Parkinson’s disease. But, clinical trials and animal studies by Johnson suggest that NAD supplements help improve memory and learning. NAD+ supplement is vital in decreasing the nerve-related inflammation associated with cognitive impairment.

2.    Reduces cholesterol

NAD+ and NAD precursors have beneficial effects on cholesterol. For instance, niacin lowers triglycerides and raise HDL cholesterol. Taking NR or NMN supplements might help lower cholesterol levels. By maintaining healthy cholesterol levels, you lower the risk of heart disease.

3.    Lowers the risk of cancer

NAD is crucial in maintaining cellular health and DNA. Lack of NAD increases the risk of cancer. Animal studies show NAD+ deficiency increases the sensitivity to UV rays, increasing the risk for skin cancer. However, NAD+ supplements can help prevent, treat, and arrest specific types of cancer.

4.    Increases energy

NAD is vital for mitochondrial function and energy production. NAD+ supplements can help deliver energy to the cells to improve their functionality. They may help improve and sustain body performance by boosting energy levels, metabolism, and circulation. Additionally, NAD boosters are claimed to help protect muscles from degradation and allow cellular processes that allow muscle recovery after workouts.

5.    Can Help Slow Down Aging

NAD is an excellent approach to improving skin’s well-being. NAD supplements are claimed to have anti-aging and life-extending benefits. Some people claim it may reverse aging on the cellular level. However, scientists report that NAD supplements have only successfully slowed aging in mice, not humans. According to Mehmel, 2020, NAD supplements affect the DNA, which may be why it helps maintain a higher life quality and potentially increase a healthy lifespan.

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How to Take NAD+ Supplements

NAD supplements are still new to the market and come in two popular forms, including oral supplements and NAD therapy. Other forms in which NAD can be administered include;

  • Sublingual solutions
  • Intramuscular injections
  • Topical solutions
  • Nasal sprays
  • Liposomal liquids

NAD+ supplements in the bloodstream are more effective than capsules or for people with difficulty swallowing pills.


Most research is done on animals and only tests short-term side effects. Clinical studies available use different doses and precursors for NAD. So, specific recommendations have yet to be established. Most studies integrate doses ranging from 100 mg to 2,000 mg.

You can try different types and see how your body responds. However, it’s crucial to talk with your healthcare provider to evaluate if the NAD supplement is right for you and their recommended dosage.

Side Effects of NAD Supplements

NAD+ supplements are generally considered safe. However, research on the long-term side effects of NAD supplements is still under investigation. Most people may experience the following side effects upon taking NAD supplements;

  • Nausea
  • Headaches
  • Fatigue
  • Diarrhea
  • Cramping during the IV therapy

Most NAD+ side effects are short-lived. But, if you feel unwell upon consuming NAD supplements, seek medical help.

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How to Increase NAD Naturally

It’s possible to boost your NAD+ levels without consuming supplements. Here are suggestions on how you can increase NAD levels in your body naturally;

  • Eat foods containing NMN. NMN is a NAD precursor in foods like cabbage, broccoli, edamame, cucumber, turkey, tomato, and avocados.
  • Use UV protection. Wearing sunscreen can help limit unprotected sun exposure, thus, helping preserve the body’s NAD levels.
  • Exercise consistently. Cardio and physical training activities like aerobics and weight lifting can increase the amount of NAD in the body without using supplements. Also, it preserves NAD+ levels.
  • Reduce calories. Research suggests that reducing calories and often fasting can help preserve NAD+ levels.


As our bodies age, they stop producing adequate amounts of NAD, leading to physical and cognitive declines. However, NAD+ supplements can help replenish the vital molecule to help prevent cancer, cognitive degeneration, and high cholesterol. More research is required to determine the specific benefits of NAD+ supplements in humans and their long-term side effects.

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